We report the case of a healthy 59-year-old woman who presented with an acute abducens nerve palsy 2 days after receiving the Pfizer-BioNTech COVID-19 vaccine. Wolf et al. These symptoms started after what I felt to be her initial presentation of COVID and she improved, then as viral load begin to drop she developed the more neurological process. The patient was diagnosed with right abducens nerve palsy [30]. OCT of the right eye showed serous macular detachment of the neurosensory retina. Herpes zoster following BNT162b2 mRNA Covid-19 vaccination in patients with autoimmune inflammatory rheumatic diseases: A case series. Ravichandran S., Natarajan R. Corneal graft rejection after COVID-19 vaccination. The Neuro Visual Center. Neurologic complications of COVID-19 are not well described. However, nine days after COVID-19 diagnosis he developed acute-onset diplopia, asymmetrical bilateral ptosis, dysphonia and dysphagia, with no reported diurnal variation and a progressive . My mother is now experiencing double vision about 30 days after her second Pfizer vaccine show. The Neuro Visual Center. As of today, it has shown no improvement. I visited with an Ophthalmologist the next morning. 8600 Rockville Pike It seems like there are some side effects of the vaccine but as doctors dont want to discourage the vaccination, no one is taking this seriously and ignoring patience everywhere. Laboratory investigations revealed a normal platelet count. Pfizer-BioNTech COVID-19 vaccine. The ocular manifestations occurred up to forty-two days after vaccination, and vaccine-induced immunologic responses may be responsible. Blauenfeldt et al. Acute-onset central serous retinopathy after immunization with COVID-19 mRNA vaccine. Its so annoying. That come goes . Diplopia (Double Vision): Background, Pathophysiology, Epidemiology US Case Reports of Cerebral Venous Sinus Thrombosis With Thrombocytopenia After Ad26.COV2.S Vaccination, 2 March to 21 April 2021. not mentioned in the article. Hello. reported that a middle-aged, previously healthy male developed a sudden onset of darkening of the visual field three days after receiving the second dose of BNT162b2 COVID-19 vaccine. The https:// ensures that you are connecting to the Thanks. We are sorry that you are going through this. What You Can Do Post-Vaccine, and When - The New York Times Each case is different so we cant comment on individual cases. MRI pending and neurology pending. I am unaware if any studies have been done relating 6th or 4th nerve palsy to viral load. I was not aware of any vision issues conducted a case series of six patients with CVST with thrombocytopenia after receiving the Ad26.COV2.S vaccine. Privacy Policy, 300 Garden City Plaza #404, Garden City, NY 11530, What To Do When Other Treatments Have Failed, Prescribing Complex Eyeglass Prescriptions, Eye Muscle Strain as the Cause of Dizziness and Headaches, Neurologist and Headache Specialist Philadelphia, PA, Have you ever felt dizzy and anxious when driving or riding in a car? The mean age of the patients was 35.2 (range 2343) years old. Ive tried all types of pain medications, but I still get headaches., My neck and the back of my head and shoulders really bother me. 2007;21:413418. We have had many cases like this. Therefore, bilateral AMN was diagnosed. This review was undertaken to help clinicians recognize the possible manifestations and systemic pathogenesis, especially those related to the eye, after receiving COVID-19 vaccination. A female patient experienced headache and visual changes six days after vaccination. Ocular Adverse Reactions after Receiving COVID-19 Vaccine I have no idea if this issue was related to the vaccine or if it is going to show up again. Blood pressure was sky high over 200 but later returned to around the 160 level. Was given a diagnosis of fourth nerve palsy and prescribed prisms for my right lens. Arashkia A., Jalilvand S., Mohajel N., Afchangi A., Azadmanesh K., Salehi-Vaziri M., Fazlalipour M., Pouriayevali M.H., Jalali T., Mousavi Nasab S.D., et al. They did a blood test for ocular myasthenia gravis which came back negative. Logunov D.Y., Dolzhikova I.V., Zubkova O.V., Tukhvatulin A.I., Shcheblyakov D.V., Dzharullaeva A.S., Grousova D.M., Erokhova A.S., Kovyrshina A.V., Botikov A.G., et al. As a library, NLM provides access to scientific literature. COVID-19 vaccines have been used under the most intensive safety monitoring in U.S. history, including studies in children 12 years and older. A day or two later i developed Adenoviral vector vaccines can cause ocular disease by inducing an immunologic response to the spike antigen or to components of the chimpanzee or human adenovirus. We screened a total of 305 titles and abstracts for eligibility. It would be hard to correlated your diplopia to the vaccine if it happened 20 days after your vaccine. One of the residents did mention that a 19 year old female had come in a week previously with a similar case. Ocular manifestations after receiving COVID-19 vaccines may appear on the eyelid, cornea and ocular surface, retina, uvea, nerve, and vessel. Although the mechanism of TTS is not clear, the clinical course and laboratory test results of TTS are similar to autoimmune heparin-induced thrombocytopenia which is triggered by the formation of PF4 antibodies [37,47]. After waiting a week for the referral to clear and be excepted by Nuro ophthalmologist the soonest appointment I could get was May 20, 2020. -. Blauenfeldt R.A., Kristensen S.R., Ernstsen S.L., Kristensen C.C.H., Simonsen C.Z., Hvas A.M. Thrombocytopenia with acute ischemic stroke and bleeding in a patient newly vaccinated with an adenoviral vector-based COVID-19 vaccine. The Neuro Visual Center, Same with me. A 53-year-old male contracted a mild case of COVID-19 in April of 2020. The MRI was unremarkable. The site is secure. I saw opthalmologist and eye exam normal except for my vision but my symptoms are still present and sometimes very debilitating. conducted a multicenter observational study on the immunogenicity and safety of the BNT162b2 vaccine in adult patients with autoimmune inflammatory rheumatic diseases. The mean age of the patients was 42.9 (range 1860) years old. [PDF] Diplopia, COVID-19 and Vaccination: Results from a Cross -. They may affect your ability to do daily activities, but should go away within a few days. A rare case of Guillain-Barr syndrome (GBS) in a patient with COVID-19 with acute respiratory distress syndrome (ARDS) after receiving Sinopharm's Vero Cell vaccine (China) is reported, and the potential of TPE for GBS treatment in critically ill patients with COvid-19 after CO VID-19 vaccination is shown. Optic neuritis with AQP4-antibody negative neuromyelitis optica spectrum disorders-like syndrome was diagnosed [29]. We are not sure if the vaccine has a correlation to your double vision. The TTS can cause thrombus formation in arteries or veins, which might lead to CVST and SOV thrombosis. Would you like email updates of new search results? The mean duration between COVID-19 vaccination and onset of retinal symptoms was 4.0 (range 115) days. reported two cases with a history of Fuchs endothelial corneal dystrophy who underwent DMEK with acute corneal endothelial graft rejection after administration of BNT162b2 COVID-19 vaccine [16]. Thank you for your reply, Dr. Israeloff. All the best. vertical double vision in my right eye, and have since gotten glasses with prisms to help correct. I was diagnosed with Covid on March 29, 2021. He returned a negative COVID-19 test. 2021 Jun 22;22(1):412. doi: 10.1186/s13063-021-05241-5. Neuro-ophthalmologic symptoms after coronavirus disease 2019 vaccination: a retrospective study. After Vaccination right away numb tongue lip and gums . However, the overall benefits of the COVID-19 vaccine in preventing COVID-19 are well established. and Y.-H.H. A 55-year-old woman presented with conjunctival congestion, retroorbital pain, and diplopia. Im hoping and praying it goes away as quickly as it arrived. My dizziness is completely gone after wearing my new glasses. All four doctors I talked to seemed very reluctant to link the symptom back to the Covid vaccine. This can be intermittent as you are describing. Additionally, the Fact Sheet for Recipients and Caregivers notes that vaccine recipients should seek medical attention right away if they develop any of the following symptoms after receiving the . I dont even wear glasses. 58-year-old patient with double vision diagnosed with COVID-19 - AOP I most appreciate your feed back. Cunningham E.T., Jr., Moorthy R.S., Fraunfelder F.W., Zierhut M. Vaccine-Associated Uveitis. Thus, other studies are needed to prove a causal link between the observed event and the vaccine, which may contribute to future vaccine development. were involved in design and conduct of study. Neurol. Had COVID in Sept. The TTS occurred mostly in middle aged women 524 days after vaccination. The mean age of these patients was 57.5 (range 4467) years old. Went to an emergency eye center the same day on Friday May 14th, all eye exams otherwise came back normal (I wear contacts so saw my optometrist only a couple months ago- always good health reports). Keywords: Guide to Double Vision (Diplopia): Causes & Best Treatment Options Brakenhoff TB, Franks B, Goodale BM, van de Wijgert J, Montes S, Veen D, Fredslund EK, Rispens T, Risch L, Dowling AV, Folarin AA, Bruijning P, Dobson R, Heikamp T, Klaver P, Cronin M, Grobbee DE; COVID-RED Consortium. Gabkak et al. The problem has improved somewhat since it started, but is still Neither test showed anything abnormal. The cases we have seen of double vision have been post COVID19, not after the vaccine. Monocular diplopia is double vision in only one eye. In adults, such palsies are typically caused by microvascular disease or compressive tumors, although they have also been described after routine vaccinations. Wolf M.E., Luz B., Niehaus L., Bhogal P., Bzner H., Henkes H. Thrombocytopenia and intracranial venous sinus thrombosis after covid-19 vaccine astrazeneca exposure. HHS Vulnerability Disclosure, Help The fever and aches went away within 2 days. Lastly, adenovirus vectors may interact with the CD46 receptor or platelet factor 4 antibodies to cause thrombosis [1]. Comparing the differences between COVID-19 vaccines Coronavirus (COVID-19) Update: July 13, 2021 | FDA Great information that people got prism lenses I will ask about these as Im currently using an eye patch. government site. The mRNA is delivered in lipid nanoparticles and induce the production of proinflammatory cytokines, such as interferon gamma (IFN), antigen-specific CD4+ and CD8+ T cell responses, and anti-spike neutralizing antibody. Bethesda, MD 20894, Web Policies I have the same experience in you. But my test of antibodies still increasing. Your healthcare provider will examine your eyes to check their position, vision, and movement. I had the 2nd dose of Pfizer vaccine on May 9th in NYC, the following morning I started to experience fever, blurred vision, aches. He was immediately sent to the emergency room. National Library of Medicine Your child cannot get COVID-19 from any COVID-19 vaccine. An official website of the United States government. Prismatic aligning lenses were prescribed to resolve the double vision. The mRNA vaccines, including BNT162b2 and mRNA-1273, contain codon-optimized sequences for spike protein synthesis and use the authentic signal sequence for its biosynthesis [41]. We can not comment on an individual case. 2022 Jan;22(1):43-55. doi: 10.1016/S1473-3099(21)00460-6. See I., Su J.R., Lale A., Woo E.J., Guh A.Y., Shimabukuro T.T., Streiff M.B., Rao A.K., Wheeler A.P., Beavers S.F., et al. Went back to the hospital for another CT scan, the following day, 4/2, still clear. I have a patient that exhibiting similar issues. Another 83-year-old female underwent DMEK six and three years prior in the right and left eyes, respectively. PMC I was wondering in the case discussed above. Hope everyone else that experiences this recovers quickly. This has also happened to me. Funduscopic examination and autoimmune or infection lab screening did not reveal any alterations. I was diagnosed with COVID-19 last October. Mambretti M., Huemer J., Torregrossa G., Ullrich M., Findl O., Casalino G. Acute Macular Neuroretinopathy following Coronavirus Disease 2019 Vaccination. Just FYI You should see a neuro ophthalmologist or neuro optometrist. I am so sorry that you are suffering so much. Moreover, mRNA vaccines may trigger endogenous glucocorticoid release to increase serum cortisol levels. I will try Vit. HHS Vulnerability Disclosure, Help Once I drove in a rain and I was seeing double vision when the windshield wiper was wiping upward but the double vision disappears when it was wiping downward. The mean duration between COVID-19 vaccination and onset of ocular symptoms was 10.0 (range 121) days. I was positive with COVID Sept 25th. It has not abated one iota, and as many others here echo it is frustrating beyond belief, particularly when the four doctors (five with the optometrist) cant see anything radical when they test me. reported that a 50-year-old previously healthy male developed slight visual impairment 11 days after receiving the first dose of the ChAdO1 COVID-19 vaccine. Patient characteristics were reviewed in three articles. This will cause double vision in the horizontal direction. A 77-year-old self-reported ethnic Chinese woman presented in January 2010 with a 6-day history of progressive ascending dysesthesia, unsteadiness, diplopia, and nausea that commenced 13 days after immunization with the seasonal influenza and novel influenza A(H1N1) vaccine. reported a 62-year-old male with a history of PKP for a corneal scar in his right eye for two years.