Xanax is used to treat the following conditions: Anxiety; Panic Disorder; Drug and food interactions These side effects may be mild or severe. This holds true for ashwagandha. A recent study looked at the health claims and safety of ashwagandha and found that the herb has shown anticancer, anti-inflammatory, heart-protective, liver-protective, and immunomodulatory (able to change the immune system) actions. Ashwagandha | Memorial Sloan Kettering Cancer Center Panda S, Kar A. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. Synthroid is not known to interact with these supplements. Jardiance,Farxiga, Invokana), ACE-Inhibitors (e.g. People who are pregnant or breastfeeding should not use ashwagandha. It is very widely utilized as a dietary supplement and used for a number of purported medical benefits, including: As ashwagandha is a botanical, it appears to have many different active components and a complex mechanism of action for how it works. Most reported drug interactions are based on the potential additive effectswhen combined with certain drugs (e.g. Some but not all ashwagandha supplements are organic. Withania somnifera improves semen quality by regulating reproductive hormone levels and oxidative stress in seminal plasma of infertile males. View abstract. View abstract. In rare cases, ashwagandha may cause liver damage. PLoS One 2009;4:e6628. These severity listings are for informational use only. View abstract. Take extra care if you are using drugs to help you relax or sleep. J Ethnopharmacol 1999;67:27-35. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Go to the ER right away. Ashwagandha: Supplement, Uses, Side Effects, Dosages, Interactions Sharma AK, Basu I, Singh S. Efficacy and safety of Ashwagandha root extract in subclinical hypothyroid patients: a double-blind, randomized placebo-controlled trial. You may think that these supplements are safe because they also have antidepressant effects, but it's not that simple. Ashwagandha - More Interactions. Fertil Steril 2010;94:989-96. View abstract. Can I Take Lexapro & Vitamin Supplements? Again, be sure to talk to your doctor about adding ashwagandha to immunosuppressant drugs. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Ashwagandha may interact with various medications. Nagashayana N, Sankarankutty P, Nampoothiri MRV, et al. When people can't obtain all of the nutrients the Food and Drug Administration recommends, they typically look into taking supplements. ashwagandha and guggul used for thyroid conditions and find out if they are beneficial. The body naturally produces thyroid hormones. In this investigation, participants took either a placebo or 240 milligrams per day of ashwagandha extract. There are a variety of vitamins and minerals that are essential for good health. https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms. lisinopril, captopril, benazepril, quinapril), ARBs (e.g. Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients. Additionally, ashwagandha may increase testosterone levels in the body. Ashwagandha has been traditionally used for anxiety, insomnia, aging, and other conditions that may be exacerbated by stress. 2021;2:72-81. doi:10.1016/j.crtox.2021.02.002. Another traditional use of ashwagandha in Ayurveda is for memory issues. Biomed Res Int 2015;2015:284154.View abstract. PLoS One 2021;16(9):e0257843. Phytother.Res 2010;24(1):129-135. They also are not very good drugs, because they have multiple potentially . Hence, be cautious if taking these medications and want to take Ashwagandha also. Ashwagandha can also interact with some medications and affect how they work. People using ashwagandha for physical performance may need to take higher doses of up to 1,250 milligrams daily to see benefits. J Funct Morphol Kinesiol. For this reason, it's always best to tell a healthcare provider if you are taking any medications and/or supplements before starting a new supplement. 2020;10(11):e01760. 4. Neurol India 2009;57:166-71. Bhattacharya SK, Satyan KS, Ghosal S. Antioxidant activity of glycowithanolides from Withania somnifera. The effect of standardized ashwagandha extract (35% withanolide glycosides) on fatigue, vitality and associated steroid hormonal systems in healthy aging, overweight men (40 to 70 years of age; BMI, 25 to 35) was investigated via a 16-week, double-blind, randomized, placebo-controlled crossover trial (N=57). One systematic review found just five human trials that studied ashwagandha as an anxiety treatment. Evid Based Complement Alternat Med. OTHER NAME(S): Ajagandha, Amangura, Amukkirag, Asan, Asana, Asgan, Ashwagandha has most often been used by adults in doses up to 1000 mg daily, for up to 12 weeks. View abstract. Safety of ashwagandha root extract: a randomized, placebo-controlled, study in healthy volunteers. As an adaptogen, helping the body resist physiological and psychological stress, Steroidal lactones (withanolides, withaferins), GLP-1 Agonists (e.g. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you take thyroid medicine, consult your doctor before using ashwagandha. Although ashwagandha is one of the more well-studied herbals on the market, there have not been extensive drug-interaction studies with it. Studies are inconclusive, but ashwagandha may have immune-stimulating properties. Front Pharmacol 2022;13:901710. Usually ashwagandha is taken 1000 mg per day, for the course of 3 to 4 months. Bhattacharya, S. K., Bhattacharya, A., Sairam, K., and Ghosal, S. Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study. J Clin Med 2021;10(16):3644. View abstract. With such a long list of claims, it's important to look closely at the research. Sehgal, V. N., Verma, P., and Bhattacharya, S. N. Fixed-drug eruption caused by ashwagandha (Withania somnifera): a widely used Ayurvedic drug. View abstract. root extract in improving cardiorespiratory endurance and recovery in healthy athletic adults. Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Which Supplements Should Be Avoided When Taking Statins View abstract. Ashwagandha might cause sleepiness and drowsiness. Therefore, it should be used cautiously with drugs used to treat diabetes, including: Just like with potential interactions between ashwagandha and diabetes drugs, there may be a potential issue with drugs used to treat high blood pressure as studies show ashwagandha mayhave blood-pressure-lowering effects. The plan to ashwagandha blood pressure medication interaction enter the company was does blood pressure medication make you put on weight quietly implemented the one from Hebei do hypertension medications affect sexuality University has already started the procedure the Yinchuan University s Zhou Qitian also agreed, and the next step is to do the school work Inner Mongolia can probiotics lower . Learn which supplements can interact with thyroid hormone medications like levothyroxine (Synthroid), thyroid hormone levels, and laboratory tests. 2008;9(6):369-374. According to an August 2016 study in the Complementary Therapies in Medicine Journal, taking ashwagandha with antidepressants like SSRIs can be a safe, effective and healthy way of supporting your mental health. . I recommend taking it at bedtime for a better night's rest or you can take it during the day. Indian J Pharmacol. J Neurol Sci 2000;176:124-7. Always talk with a healthcare provider before starting any new supplement regimen. Ashwagandha interacts with 623 drugs. Byetta, Trulicity, Ozempic, Rybelsus, Bydureron, Victoza, Mounjaro), Sulfonylureas (e.g. Animal research and one case study indicate that the herb might increase serum concentration of thyroid hormones, according to Ray Sahelian, a medical doctor who specializes in natural supplements. Doctors prescribe immunosuppressants for people with conditions such as rheumatoid arthritis, psoriasis and ulcerative colitis, and to prevent rejection of organ transplants. Some products may not mix well with other drugs or natural products. Myxedema Coma. However, certain vitamins, supplements and medications are processed via the same enzymatic pathway (cytochrome P450) as your antidepressants. Ashwagandha might increase the sedative effects of benzodiazepines, prescribed for conditions such as panic disorder and anxiety, and of barbiturates, primarily used for epilepsy. Read more: 15 Celebrities Who Struggle With Anxiety and Depression. Upadhaya L and et al. The liver damage never progressed to liver failure, and most cases were resolved within five months. Ashwagandha is native to India and Southeast Asia and is one of the most important herbs in Ayurveda, an alternative natural system of medicine that originated in Indian over 3,000 years ago. Health Sci Rep 2022;5(4):e741. Do not use this product if you have stomach problems or ulcers. National Library of Medicines list Anbalagan K and Sadique J. Withania somnifera (ashwagandha), a rejuvenating herbal drug which controls alpha-2 macroglobulin synthesis during inflammation. Ashwagandha has not been well studied in regard to potential interactions with prescription medication. 2019;11(10):2362. doi:10.3390/nu11102362, Zhu C, Zhang Y, Wang T, et al. These are drugs like diazepam, lorazepam, phenobarbital, or zolpidem. doi:10.7759/cureus.6466, Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: a randomized, double-blind, placebo-controlled study. DISCLAIMER: Currently this does not check for drug . Agarwal R, Diwanay S, Patki P, Patwardhan B. Do not use this product if you are pregnant or plan to become pregnant soon. Levothyroxine is in the drug class thyroid drugs . Phase III randomized clinical trial of BV-4051, an Ayurvedic polyherbal formulation in moderate SARS-CoV-2 infections and its impact on inflammatory biomarkers. Ashwagandha - Diazepam Interaction Details | HelloPharmacist Skinmed. Indian J Exp Biol 2000;38:607-9. Discard any remaining ashwagandha supplements once they expire or as indicated on the packaging. Dongre S, Langade D, Bhattacharyya S. Efficacy and safety of ashwagandha (withania somnifera) root extract in improving sexual function in women: a pilot study. Patients must speak with a health care provider for complete information about their health, medical questions, and treatment options, including any risks or benefits regarding use of medications. Ashwagandha And Lexapro (An Overview) | OptimistMinds Should You Take Ashwagandha for Thyroid Issues? - Healthline Fortunately, no cases resulted in liver failure, and all recovered. Staff. Ashwagandha may have additive effects to certain drugs that are used for diabetes, high blood pressure, and low thyroid hormone, to name a few. Take ashwagandha with these drugs only under your doctor's supervision, recommends the Langone Medical Center at New York University. A total of 525 drugs are known to interact with Xanax. Curr Res Toxicol. ashwaganda: Dosing, contraindications, side effects, and - Epocrates 8-16-1995;95(1-2):189-193. Although, it's important to note that long-term studies have not been performed on ashwagandha. Effect of Indian Ayurvedic medicine Ashwagandha on measurement of serum digoxin and 11 commonly monitored drugs using immunoassays: study of protein binding and interaction with Digibind. However, these results have not been proven in humans. Ashwagandha is not naturally found in foods, which means the only way to get it is through supplements. 2017;10(3):96-100. doi:10.5935/1984-0063.20170018. 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