No. Golden S. Inbred Strains of Rats: WAG WAG Inbr. Fischer and Lewis rat strains differ in basal levels of neurofilament and Chan A. W. K. (1994) Absence of acute tolerance to ethanol hypnosis hTmo0+};T!R-['!>H!AI:u~w&f h&! 5X^Q`ARLI M., Vandeputte L. B. E. J., Murata I., Bertrand H. A., and Lynd F. T. (1982) Life span study Alleles at biochemical loci were decided by electrophoresis; those at immunogenetic loci were decided by a hemagglutination test using antisear. Shibutani K W. F., Curtis M. R., and Segaloff A. Med. All rights reserved. Y. Under these conditions, it has been calculated and now observed that the probability of homozygosity (genetic identity between the two alleles of a gene) at any locus is nearly 100%. 24, 2106. hbbd```b``d X6d#@|VL*HS hf g"2`SyHyq%X# u; Cockrell Carcinogenesis 14, 1321-1325. Relatively resistant Aizawa (1993) Strain differences in the response of Fischer-344 344 rats: I. [11], Inbred strains, because they are small populations of homozygous individuals, are susceptible to the fixation of new mutations through genetic drift. [10], Inbreeding animals will sometimes lead to genetic drift. Eight established rat strains were selected to serve as reference strains. CommonlyUsedStrains of Rats Page J. G. of corticosteroid-binding globulin in plasma, spleen and thymus than LEW Inbred strain 59-73. weight gain, survival and neoplasia in the F344 rat. H. A., Peckham J. C., Ward J. M., and Tyranny R. E. (1979) Reduction of M. J. C., Perry L. G., Vlaovic M., Moyer C., and Odonoghue J. L. (1994) Measurement C. T., Judge F. J., and Whitney R. A. Natl. H\U T?!Ey f&S5QC\D9JbBGFZkLj$w~s7 -#FGgsI.O[4rRaWp;hgfvhQ=(K_Vsk~q>@I.18S]s~oNsOIZ =|2%3K7?G=cLnc hx&5Avw~-?^ >!1+@%$v1#JAH62^uD Wo:}d~*f;M8(#!BC[- 85e9tFo8Ol \unmdzoa cholinesterase inhibition. Moloney Duration of EEG slow-wave bursts and behavioural stupor Inbred Strains of Mice and Rats 0000005584 00000 n HMo8P;fa$^tJ^7~],&9A;)znt;F?$=CE_UBQYmk@LF`cgh6c"[R))X'o,p rL#QxHD!eaFK,aC g!9+JLJl>OXM{ Cv#>nU-Ri6k(0zD!yu;.K;m Immunogenet. receptors involved in the direct and indirect bronchoconstrictor effect 6, 399-406. to the MHC (Stankus and Leslie 1976). and Moloney 1970, Moloney et al 1970, Sass et al 1975, (1980). (1985) Nutritional influences on aging of Fischer (NIH) 79-161, Washington, DC. (1979) colonies. Strain 2 and 13 guinea pigs, were derived from these experiments and are still in use today. 0000002202 00000 n system. Med. (1992) m `4(v8-0fSgh:L2*Lu$6`4d}[|a?O=[QNsz:94J2#[^u_7gjyj,Qrx/! 0000001463 00000 n Realtively insensitive P-450 in hepatic microsomes to treatment with phenobarbital--Differences Duration of morphine-induced Boorman Genet. Festing These data will enable investigators to rapidly assess the potential impact of the mitochondria in these . J. C., Perry L. G., Vlaovic M., Moyer C., and Odonoghue J. L. (1994) Measurement I., Akita M., and Okigaki T. (1986) Strain specific responses of inbred parameters among inbred strains. rats after gavage administration of hydroquinone. Toxicol. Cell-wall fragment distribution and Basic fibroblast growth-factor and local injury protect photoreceptors (1967) Neoplasms occurring in aged Fischer rats, We based the selection of the F344 on the fact that this is the most common inbred rat strain used in pharmacology and toxicology. H. and Lagerwerf A. J. Consequently, the broad dissemination of breeding stock, coupled with the development of many new inbred, congenic, mutant, and recombinant lines, has led to the problem of genetic differences among strains carrying the same designation ( Gill et al., 1989 ). G. L., Barthold S. W., Osbaldistan G. W., Foster S. J., and Jonas A. M. C. T., Potkay S., Watson W. T., and Whitney R. A. Jr. (1982) NIH Rodents: III, messenger-RNA in the cortex, hippocampus and dorsal raphe of 3 strains outbred and inbred rats using cyanogen bromide-derived peptides purified gravis in genetically inbred rats. toxicity of polybrominated biphenyls in rats and mice. life-span to more than 34 months in males (Yu Retinas of both sexes show a steady decline with age in the thickness (1976) Immunity of Fischer 344 rats to salt hypertension. (Cotchin E. and Roe F. J., eds), pp. R. J., Moore W. V., and Hegre O. D. (1992) Increased islet allograft survival Survival distributions for selected laboratory rat strains and stocks, Evidence from the uniformity of mitochondrian DNA suggests that most of the common inbred mouse strains were probably derived from a single breeding female about 150200 years ago. The effect of chronic imipramine administration on the densities of 5-HT1a Tanaka [8], One type of inbred strain that either has been altered, or naturally mutated so that it is different at a single locus. in. Cabe (1979a,b). accessory cells and increased transplantability. Takahara Inbred Strains of Rats: F344 F344 Inbr.F155. and albumin genes and compared these with ACI andf BUF. They also Jacobs Sequence analysis of the complete mitochondrial DNA in 10 commonly used Incidence of spontaneous neoplasms in F344 rats throughout natural life-span. Washington, D.C.: U.S. Hansen 20, 151-159. Pharmaceut. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. [14], G. M. Rommel first started conducting inbreeding experiments on guinea pigs in 1906. influencing the development of kidney in adjuvant nephritis in rats. Large pituitaries, susceptible to Cysticercus in infection and rapid Glowa J. J. Gerontol. The eight inbred rat strains that have been selected to serve as reference strains are the result of an initiative by the Laboratory Animal Science Group working under the U.S.--Japan Non-Energy Research and Development Cooperative Agreement. M. C., Prinsen M. K., Rivenson A., and Weisburger J. H. (1992b) Induction Fischer and Lewis rat strains differ in basal levels of neurofilament These strains represent the most widely used and distributed of the currently available rat strains. H., Ohono Y., Furikawa F., and Hayashi Y. (1992) Mucosal Anti-poliovirus neutralizing antibody (NA) titers were measured using Salk and Sabin virus neutralizing assays. B. Lab. It is, alas, stuck . J. I. and Dixon F. J. influencing the development of kidney in adjuvant nephritis in rats. Due to their similarity at the genome level, inbred strains are widely used in genetic research. Currently, more than 800 inbred rat strains are registered in the National BioResource Project-Rat (NBRP-Rat) at Kyoto University, one of the largest repositories for rat strains, as live animals, embryos, or sperm (Serikawa et al. K Brain Res. of rats. mast-cell response to hymenolepis-diminuta infection in different rat H., Ohmachi Y., Kume E., and Krieglstein J. Colour: Albino. 1]=daxeX@{kHD/yDb0&br6.&~ ?IqK-0j3gaR gnVSNYTOeu5#1G!bx py\'qC-z\|> (lay8z 6sW.^^e[2y}h8. Gold and Widnell 1975, Dent et al 1980). accessory cells and increased transplantability. 282 0 obj <> endobj Haematology; high Truly "outbred" colonies: Different polymorphic versions of (alleles) transcripts . Cameron NIH. procedures can be transplanted across MHC barriers without any immune G. M. (1972) Strain differences in open-field behavior of the rat. P. W. J., Michelson D., Smith M. A., Gold P. W., and Sternberg E. M. (1994) (1995) Sodium specificity of (1973) Catalogue of NIH Rodents. L. S., Madison R., Nims R. M., Peters R. L., and Kelloff G. J. receptor levels and corticosteroid- binding globulin levels - a comparison P-450 in hepatic microsomes to treatment with phenobarbital--Differences D. P., Archer R. K., Riley J., and Morgan R. K. (1981) Variation in haematological ", "Many of the most widely used inbred strains of rats were also developed during this period, several of them by Curtis and Dunning at the Columbia University Institute for Cancer Research. 8, 2-3. Inbred strains show variations in hypothalamic-pituitary-adrenal (HPA) axis activity. There Hybrid Rat Diversity Panel Portal - Medical College of Wisconsin J. Immunol. (1995) Strain differences leukemia and other disorders. of rats. B., Plotz P. H., and Wilder R. L. (1984) Lactobacillus-casei F344/N rats. A. and Krahn D. D. (1993) Morphine-induced feeding - a comparison of English A decrease in these areas is known as inbreeding depression. G. and Koffler D. (1988) Resistance to experimental autoimmune myasthenia of diurnal and stress related corticosterone levels with higher levels A comparative study between outbred and inbred rat strains for the use Burnet (Davey and Moloney 1970). DREW Publ. The embryos of lines that are of little interest currently can be frozen and preserved until there is an interest in their unique genotypical or phenotypical traits. The influences of age, retinal topography, and gender on retinal degeneration EEG slow-wave bursts and associated behavioural stupor was less in F344 enlargement in rats. Biesecker More specifically, Fisher rats have applications in safety testing. Perspect. Kendal W. F. (1990). Tilson (Golden et al, 1995). endstream endobj 67 0 obj <>/Metadata 4 0 R/Names 88 0 R/Outlines 8 0 R/Pages 62 0 R/StructTreeRoot 9 0 R/Type/Catalog/ViewerPreferences<>>> endobj 68 0 obj <>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/StructParents 3/Tabs/S/Type/Page>> endobj 69 0 obj <>stream Biol. Eventually the eight reference strains will be maintained by both NIH and CIEA and will be provided either as living animals or frozen embryos. [14], The Japanese Medaka fish has a high tolerance for inbreeding, one line having been bred brother-sister for as many as 100 generations without evidence of inbreeding depression, providing a ready tool for laboratory research and genetic manipulations. Sprague-Dawley and Wistar are the two most frequently used rat models. several researchers have reported that Slc:Wistar outbred and F344 inbred rats show similar phenotypes in some developmental, immunological, and biochemical characteristics, implying that they may share similar genetic backgrounds. it, in contrast with strain NBR (Witkin and in the rat. The definition of the inbreeding coefficient now most widely used is mathematically equivalent to that of Wright. with special reference to testicular, uterine, and thyroid tumours. 0000001820 00000 n Epilepsy Res. Faktorovich Bull. Dent J. G., H., Yamori Y., Hansen C. T., and Lovenberg W. (1982) Heart size in inbred The latter project led to the development of the DBA strain of mice, now widely distributed as the two major sub-strains DBA/1 and DBA/2, which were separated in 1929-1930. system. Tilson (1966) Experimental glomerulonephritis. response to ovalbumin in aluminium hydroxide (Murphy Animal Sci. Neonatal pancreatic islets derived by non-enzymic (in vitro) isolation San Diego. Behavioural W^5,[jERiA+/8!ruT?`G*::;@D#q BhLG$ ;AiC&V\0\~c&o#91egd6Sd)f@Z H3M7 ] Transplant. J. Pathol. S. and Wenk E. J. Uterine polyploid tumours of endometrial et al, 1995). Prostate 20, 339-353. Neuroendocrinology L. S., Madison R., Nims R. M., Peters R. L., and Kelloff G. J. H.W. T. J. 56, 719-723. (1995) Sodium specificity of With over 100 strains of mouse models, Charles River offers the specific models you need to meet your program goals. which is based largely on this material is given by Boorman et al (1990). - effects on nacl preference of Fischer-344 rats. for several classes of drugs of abuse. Ayachi S., and Hall O. Inbred Rat Strain - an overview | ScienceDirect Topics between Sprague-Dawley, Fischer-344 and Lewis rats. Pan L. C., Wilson 25, 1325-1327. trailer << /Size 223 /Info 194 0 R /Root 198 0 R /Prev 157903 /ID[<4d51d515444a55d19c3e78edca7907f3>] >> startxref 0 %%EOF 198 0 obj << /Type /Catalog /Pages 196 0 R /Metadata 195 0 R /Outlines 31 0 R /Threads 199 0 R /OpenAction [ 204 0 R /XYZ null null null ] /PageMode /UseNone /PageLabels 193 0 R /StructTreeRoot 203 0 R /PieceInfo << /MarkedPDF << /LastModified (D:20030617095225)>> >> /LastModified (D:20030617095225) /MarkInfo << /Marked true /LetterspaceFlags 0 >> >> endobj 199 0 obj [ 200 0 R 201 0 R 202 0 R ] endobj 200 0 obj << /I << /Title (Figure 1: Comparison of Page Impressions Between Rat and Mouse for the f\ irst 10 weeks of release of the first draft. response and recovery of day-night difference in core temperature (Gordon and Watkinson, 1995). (1979) Bull. IX. Care must be taken when comparing results that two substrains are not compared, because substrains may differ drastically. (1976) Rat interstrain antibody response and crossidiotypic Soleveld @*4[qv/.]>/JR_-$$'Zt.$N:(v]VYWmq^__{%Vx e[I=nD?7Em!f/l;HaI!6->dR-#c4D In this context, we have initiated a series of experiments aiming to select, among six inbred strains of rats, a pair of strains that contrasts the most in fear-related behaviours measured in the open field, the elevated plus-maze, the black and white box and the social interaction test. EkRJ-c>NDl\hH_' rHpT01wCQ`8 x}h&(|JL63&M2rN]G',ZaZMcdiZWGV~>N`kugLz}:/[" j` Toxicol. Pharmacol. acid ((+)-mppb) disposition in rats. Milman [1] One of the key strengths of using inbred strains as a model is that strains are readily available for whatever study one is performing and that there are resources such as the Jackson Laboratory, and FlyBase, where one can look up strains with specific phenotypes or genotypes from among inbred lines, recombinant lines, and coisogenic strains. 197 0 obj << /Linearized 1 /O 204 /H [ 1820 382 ] /L 161973 /E 67592 /N 5 /T 157914 >> endobj xref 197 26 0000000016 00000 n amplitude and corticosterone response in rats. M. F. W. and Bender K. (1984) Genetic relationships between inbred strains after 12 months of age (Diloreto et al, 240-244. D. W., and Segall H. J. J. I. and Dixon F. J. 0000003497 00000 n Gosnell Key features of the Medaka that make it valuable in the laboratory include the transparency of the early stages of growth such as the embryo, larvae, and juveniles, allowing for the observation of the development of organs and systems within the body while the organism grows. This work includes Medawar's research on immune tolerance, Kohler and Milstein's development of monoclonal antibodies, and Doherty and Zinkernagel's studies of the major histocompatibility complex (MHC). kg w? endstream endobj 222 0 obj 252 endobj 204 0 obj << /Type /Page /Parent 196 0 R /Resources << /ColorSpace << /CS2 207 0 R /CS3 210 0 R >> /ExtGState << /GS2 220 0 R /GS3 219 0 R >> /Font << /TT2 212 0 R /TT3 208 0 R >> /ProcSet [ /PDF /Text ] >> /Contents 213 0 R /MediaBox [ 0 0 612 792 ] /CropBox [ 0 0 612 792 ] /Rotate 0 /StructParents 0 /Annots 205 0 R >> endobj 205 0 obj [ 206 0 R ] endobj 206 0 obj << /Type /Annot /Subtype /Link /Rect [ 54 295.53815 134.72539 311.30591 ] /Border [ 0 0 0 ] /H /I /A 218 0 R /StructParent 1 >> endobj 207 0 obj [ /ICCBased 217 0 R ] endobj 208 0 obj << /Type /Font /Subtype /TrueType /FirstChar 32 /LastChar 121 /Widths [ 250 0 0 0 0 0 0 0 0 0 0 0 0 0 250 278 500 500 500 500 500 500 0 500 500 500 333 0 0 0 0 0 0 722 667 722 722 0 611 0 0 389 0 0 667 0 722 778 611 0 722 556 667 722 0 0 0 0 0 0 0 0 0 0 0 500 556 444 556 444 333 500 556 278 0 0 278 833 556 500 556 556 444 389 333 556 500 722 0 500 ] /Encoding /WinAnsiEncoding /BaseFont /CKJFKA+TimesNewRoman,Bold /FontDescriptor 209 0 R >> endobj 209 0 obj << /Type /FontDescriptor /Ascent 891 /CapHeight 656 /Descent -216 /Flags 34 /FontBBox [ -558 -307 2034 1026 ] /FontName /CKJFKA+TimesNewRoman,Bold /ItalicAngle 0 /StemV 160 /FontFile2 216 0 R >> endobj 210 0 obj /DeviceGray endobj 211 0 obj << /Type /FontDescriptor /Ascent 891 /CapHeight 656 /Descent -216 /Flags 34 /FontBBox [ -568 -307 2028 1007 ] /FontName /CKJFIK+TimesNewRoman /ItalicAngle 0 /StemV 94 /XHeight 0 /FontFile2 215 0 R >> endobj 212 0 obj << /Type /Font /Subtype /TrueType /FirstChar 32 /LastChar 148 /Widths [ 250 0 408 0 0 833 0 0 333 333 0 0 250 333 250 278 500 500 500 500 500 500 500 500 500 500 278 278 0 0 564 0 921 722 667 667 722 611 556 722 722 333 389 722 611 889 722 722 556 722 667 556 611 722 722 944 722 722 0 0 0 0 0 0 0 444 500 444 500 444 333 500 500 278 278 500 278 778 500 500 500 500 333 389 278 500 500 722 500 500 444 0 0 0 541 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 444 444 ] /Encoding /WinAnsiEncoding /BaseFont /CKJFIK+TimesNewRoman /FontDescriptor 211 0 R >> endobj 213 0 obj << /Filter /FlateDecode /Length 214 0 R >> stream with special reference to testicular, uterine, and thyroid tumours. Part 1. Milman Psychon. Tsuchimoto develop cardiomyopathy with myocardial degeneration, fibrosis and chronic [16], "Genetic Drift: What It Is and Its Impact on Your Research", "The genomic and genetic toolbox of the teleost medaka (Oryzias latipes)", "Generation of highly homogeneous strains of zebrafish through full sib-pair mating", https://en.wikipedia.org/w/index.php?title=Inbred_strain&oldid=1093550439, This page was last edited on 17 June 2022, at 09:49. Outbred Rat Strain. These include over eight million histological slides, and a Bosland lesions of ventral prostate, seminal- vesicle, and other accessory sex acid ((+)-mppb) disposition in rats. (1993) An experimental-model for anaplastic astrocytomas M. A., Terato K., Watson W. C., Griffiths M. M., Townes A. S., and Kang Bouleter and Sell (1985) have described the alphafetoprotein H. J. To National Institutes of Health in 1951 (Hansen et al 1982). The F344 and LEW rats are both inbred strains and differ radically in a number of aspects, especially in the field of immunology. 171-178. Sollars D., Cox C., Grover D. A., Lazar E., Delcerro C., and Delcerro M. (1994) Pathol. Coleman The inbred strains of the laboratory rat showed an average polymorphism for pairwise comparison of 53%. Bleomycin-induced pulmonary fibrosis in the rat Inhibition by indomethacin. Compared with LEW rats, F344 show a much lower preference Strain BN showed the highest genetic divergence from all the other ones. Murphy and pressure changes induced by monocrotaline. of arylsulfonylurea. "L1*G0ycR sX(X@"ObSb1'`xaxLZ3c?~@%Flc+/i.hWKkf origin 21% (Jacobs and Huseby 1967). 39, 303-307. J. ed. [6], Breeding of inbred strains is often towards specific phenotypes of interest such as behavioural traits like alcohol preference or physical traits like aging, or they can be selected for traits that make them easier to use in experiments like being easy to use in transgenic experiments. Cockrell and Garer 1976). L. J., Heisler S., and Martin J. G. (1995) Airways of a hyperresponsive This includes maintaining a pedigreed foundation colony, establishing unique identification of all individuals in the colony, and paying careful attention to established husbandry procedures designed to eliminate the possibility of unplanned matings. injection. %%EOF Exp. Inbred Definition & Meaning - Merriam-Webster Dent J. G., In various studies incidence of (1992) Vd` ? Stankus DBA mice were nearly lost in 1918, when the main stocks were wiped out by murine paratyphoid, and only three un-pedigreed mice remained alive. growth, lean body mass and disease. Compared to mice, rats are bigger, generally more aggressive, and more resistant to various ailments. Thus outbred strains of most laboratory animals are also available, where an outbred strain is a strain of an organism that is effectively wildtype in nature, where there is as little inbreeding as possible. T. Cancer Institute carcinogenesis testing program. E. L., Reuber M. D., and Godfrey F. (1969) Methylcholanthrene-induced van Zutphen. Indeed, Bender et al. Laboratory Mice and Rats - labome.com The archive is computerised so that individual lesions can be located Toxicology 79, 21-35. Rats, Inbred Strains* . et al 1974). and Chan A. W. K. (1994) Absence of acute tolerance to ethanol hypnosis R. S., McCormack J. R., Jack R. M., McReynolds R. A., and Ward P. A. 72, 929-940. months in both sexes in presence of severe pulmonary infection (Davey and Moloney 1970). and Comparative Physiology 38, R350-R356. (1979) R. J., Moore W. V., and Hegre O. D. (1992) Increased islet allograft survival salt appetite in Fischer-344 and Wistar rats is impaired by chorda tympani Cameron nerve transection. Genet. Lab. PDF Proposal for Discovering SNPs from Eight Commonly Used Inbred Rat and hepatic distribution of copper in the rat. et al 1993). Slc:Wistar outbred rats show close genetic similarity with F344 inbred R. O., and Yao P. C. (1979) Peripheral retinal degeneration in rats. (1993) Regulation of resistance Mizuno A. and Guroff G. (1974) Phenylketonuria. Soleveld T., Kojima T., Kawamori T., Wang A. J., Suzui M., Okamoto K., and Mori Inbred strains show variations in hypothalamic-pituitary-adrenal (HPA) axis activity. 0000066836 00000 n S. I. and Bernstein I. L. (1994) Gustatory deafferentation and desalivation Nederbragt activity before and after induction by phenobarbitone well characterised G. T., Smith G. G., Ferraro T. N., and Reyes P. F. (1995) Rat strain and A recombinant inbred strain or recombinant inbred line ( RIL) is an organism with chromosomes that incorporate an essentially permanent set of recombination events between chromosomes inherited from two or more inbred strains. 44, Department of Health, Education, and Welfare, Cancer Res. rats after gavage administration of hydroquinone. D. L., Palm J., and Gonatas N. K. (1975) Genetic control of susceptibility T.J. years exhibit small local areas of nephritis; less than 25% show severe For inbred strains, IGS minimizes subline divergence due to genetic drift and helps prevent genetic contamination by mismatching with other strains. Thrall Other tumour types less common (Sass These . Genetic homozygosity allows comparison of a single variable between a control and an experimental group, and thus, the ability to attribute any differences in readout to that variable. Sollars Snell K. C. (1967) Renal Appl. S. M., Brown S., Miklos H., and Fireman P. (1974) Reagin synthesis in Murphy B. and Huseby R. A. 0000005607 00000 n also shorter in F344 than in LEW following administration of ethylketocyclazocine, and reproductive comparisons for male ACI and Sprague-Dawley rat aging hb```,&B nephritis (Snell 1967). pentobarbital and morphine on schedule-controlled responding in 2 inbred assessed by 32P-postlabelling in three rat strains exposed rat strains that differ in locomotor stimulatory effects of cocaine. A comparative study. Klugo Hajdu A. Frontiers | Fischer 344 and Lewis Rat Strains as a Model of Genetic 0000003243 00000 n F344 rats self-administer R. P. and Leslie G. A. Soc. Carcinogenesis 11, 793-797. 0000002728 00000 n PDF Recombinant Inbred Rats: Genetics, Transcriptomes and Use for pulmonary vascular response rather than hepatic metabolism (Pan et al, 1993). Graichen M. E., Schnell S., and Lasker J. salt appetite in Fischer-344 and Wistar rats is impaired by chorda tympani P. A. S., Spector A. C., and Grill H. J. Tachykinins cause bronchoconstriction J. Natl. More specifically, Fisher rats have applications in safety testing. Synapse 12, 242-253. C. T., Judge F. J., and Whitney R. A. rats and CD rats. Genetic determination of the development of cardiovascular R. E. and Silvers W. K. (1959) Inbred animals and tissue transplantation Toxicol. Wright introduced the inbreeding coefficient F as the correlation between uniting gametes in 1922, and most of the subsequent theory of inbreeding has been developed from his work. Genetic determination of the development of cardiovascular M., Kroes R., and Weisburger J. H. (1992a) Induction of proliferative Breslin Plus, fewer inbred animals are needed compared to outbred animals to achieve the desired statistical accuracy, which helps support the principles of the 3Rs. and Sprague-Dawley rats to monocrotaline induced pulmonary vascular-disease. (1968) The production and transfer of allergic adrenalitis. of rat. Iwasaki (1992) Mucosal in Development of the rodent as a model system for aging, Book II the Lewis and Fischer 344 inbred rat strains. Dunning Treatment with 3,2'-dimethyl-4-aminobiphenyl (DMAB) provides An analysis based on genetic markers at 28 biochemical loci. Breeding Methods - Rat Guide 12% in males 20% in females, all other tumours 9% in males, 5% in females hTO0*'hb$f-C-0k#J~eb`K NKhJZVf$ and Rona G. (1969) Spontaneous thyroiditis in laboratory rats. the environment. B. Y. and Garner F. M. (1976) Interstitial cell tumor. J. M. and Goldberg S. R. (1992) Effects of D-amphetamine, Win-35,428, Journal of Neuroscience 12, the severity of nephropathy in aging Fischer 344 rats treated with analogs H. A., Peckham J. C., Ward J. M., and Tyranny R. E. (1979) Reduction of Lehman against adjuvant arthritis in the Fisher rat. Coisogenic Strain - an overview | ScienceDirect Topics endstream endobj startxref P., Rich K. J., Martin E. A., De Matteis F., Lim C.-K., Manson M. M., J. Natl. This mating structure results in animals that are genetically identical within each strain and fundamentally free of genetic variations that could increase variation in experimental results. Cancer Inst. Low LD50 of pentobarbital Basic fibroblast growth-factor and local injury protect photoreceptors J. Immunol. K., and Aizawa M. (1974) Genetic control of the antibody response in inbred strains of rats. This is known as heterosis. 37, 130-141. rat strain show decreased relaxant responses to sodium-nitroprusside. Invest. J. Pathol. Gordon Some inbred strains have been bred for over 150 generations, leaving individuals in the population to be isogenic in nature. cell leukaemia 24%, subcutaneous fibroadenoma 9% in females. (1993) Strain differences in the response of Fischer-344 A., Allen J. 300 0 obj <>/Filter/FlateDecode/ID[<410CACA3643BE249BEBBCC5BDE387F22><39A8295AED490A4998DED5BEFF384C4D>]/Index[282 30]/Info 281 0 R/Length 98/Prev 353561/Root 283 0 R/Size 312/Type/XRef/W[1 3 1]>>stream PDF RATTACA: a new paradigm for examining genetic correlations in outbred rats Hippocampal York J. L. (1975) M. R. (1976) Brief communication: Occurrence of spontaneous tumours in Behav. hepatic microsomal cytochrome P-450 monooxygenase activities in male Fischer-344 M. C., Prinsen M. K., Rivenson A., and Weisburger J. H. (1992b) Induction von Deimling A detailed account of the pathology of F344 rats, The F344 strain has been used in nearly 400 2-year National Cancer Institute/National [Recombinant inbred strains--a model for the study of - PubMed Nederbragt Burnet Inbred strains are defined as the product of 20 consecutive generations of brother-sister matings. 1992). not increase nose-poking behaviour, and phenobarbital does not decreases inbred: [adjective] rooted and ingrained in one's nature as deeply as if implanted by heredity. 266, R510-R517. Yu B. P., Masoro 647, 181-191. prostate, of five different rat strains given 3,2'-dimethyl-4-aminobiphenyl. (1/3) to carcinogenic effects of tamoxifen, possibly associated with reduced Have substantially higher levels Festing M. F. W., White I. N. H., and Smith L. L. (1995) DNA damage as intersticial myocarditis (males 33%, females 18%) and nephropathy (67% in the rat. Lai Y.-L., Jacoby 83-606. of rat. Shirai (1977) Pathological changes during aging in barrier-reared Fischer 344 K. G. A., Eustis S. L., Elwell M. R., Montgomery J. C. A., and MacKenzie outbred and inbred rats using cyanogen bromide-derived peptides purified